| Transactions |
| Date | Team | Player | Type | OthTm | EffDate | When |
| 4/10/2021 | DUR | Andrus | Traded away | NDF | | After |
| 4/10/2021 | DUR | Escobar | Acquired via trade | NDF | | After |
| 4/10/2021 | DUR | Fowler | Acquired via trade | NDF | | After |
| 4/10/2021 | DUR | Johnson,D | Traded away | NDF | | After |
| 4/11/2021 | DUR | Castano | Placed on Injured List | | 4/8/2021 | Before |
| 4/11/2021 | DUR | Cole,AJ | Promoted to active roster | | | Before |
| 4/11/2021 | DUR | Encarnacion | Demoted to reserve roster | | | Before |
| 4/11/2021 | DUR | Escobar | Promoted to active roster | | | Before |
| 4/11/2021 | DUR | Kendrick | Promoted to active roster | | | Before |
| 4/11/2021 | DUR | Machin | Demoted to reserve roster | | | Before |
| 4/11/2021 | DUR | Paredes,E | Promoted to active roster | | | Before |
| 4/11/2021 | DUR | Perez,R | Demoted to reserve roster | | | Before |
| 4/11/2021 | OLL | Crawford,B | Placed on Injured List | | 4/9/2021 | Before |
| 4/11/2021 | OLL | Gordon,D | Promoted to active roster | | | Before |
| 4/11/2021 | PRO | Berti | Placed on Injured List | | 4/10/2021 | Before |
| 4/11/2021 | PRO | Romano,J | Placed on Injured List | | 4/9/2021 | Before |
| 4/11/2021 | PRO | Tejeda | Promoted to active roster | | | Before |
| 4/11/2021 | PRO | Webb,J | Promoted to active roster | | | Before |
| 4/14/2021 | CAL | Arraez | Placed on Injured List | | 4/14/2021 | Before |
| 4/14/2021 | CAL | Sano | Promoted to active roster | | | Before |
| 4/14/2021 | DUR | Kendrick | Acquired via trade | HAV | | After |
| 4/14/2021 | DUR | Shreve | Traded away | HAV | | After |
| 4/14/2021 | OLL | Schwarber | Demoted to reserve roster | | | Before |
| 4/14/2021 | OLL | Ward | Promoted to active roster | | | Before |
| 4/14/2021 | PRO | Oliva | Promoted to active roster | | | Before |
| 4/14/2021 | PRO | Smith,R | Demoted to reserve roster | | | Before |
| 4/20/2021 | HOL | Casali | Placed on Injured List | | 4/20/2021 | Before |
| 4/20/2021 | HOL | Ruiz,K | Promoted to active roster | | | Before |
| 4/20/2021 | OLL | Crawford,B | Activated from Injured List | | | Before |
| 4/20/2021 | OLL | Ward | Demoted to reserve roster | | | Before |
| 4/20/2021 | PRO | Oliva | Demoted to reserve roster | | | Before |
| 4/20/2021 | PRO | Smith,R | Promoted to active roster | | | Before |
| 4/20/2021 | PRO | Tejeda | Promoted to active roster | | | Before |
| 4/20/2021 | PRO | Webb,J | Promoted to active roster | | | Before |
| 4/20/2021 | RMH | Flowers | Placed on Injured List | | 4/20/2021 | Before |
| 4/20/2021 | RMH | Lopes,T | Promoted to active roster | | | Before |
| 4/23/2021 | HOL | Cueto | Promoted to active roster | | | Before |
| 4/23/2021 | HOL | Urias,J | Placed on Injured List | | 4/22/2021 | Before |
| 4/23/2021 | OLL | Morejon | Promoted to active roster | | | Before |
| 4/23/2021 | OLL | Ynoa | Demoted to reserve roster | | | Before |
| 4/23/2021 | PRO | Romano,J | Activated from Injured List | | | Before |
| 4/23/2021 | PRO | Webb,J | Demoted to reserve roster | | | Before |
| 5/1/2021 | PBL | Fisher | Traded away | CED | | After |
| 5/1/2021 | PBL | Sierra | Acquired via trade | CED | | After |
| 5/2/2021 | AUR | Jansen,D | Demoted to reserve roster | | | Before |
| 5/2/2021 | AUR | Pina | Promoted to active roster | | | Before |
| 5/2/2021 | CAL | Arraez | Activated from Injured List | | | Before |
| 5/2/2021 | CAL | Hernandez,D | Demoted to reserve roster | | | Before |
| 5/2/2021 | CAL | Hernandez,D | Promoted to active roster | | | Before |
| 5/2/2021 | CAL | Kemp,M | Demoted to reserve roster | | | Before |
| 5/2/2021 | PBL | Sierra | Promoted to active roster | | | Before |
| 5/2/2021 | PBL | Stewart,DJ | Placed on Injured List | | 4/29/2021 | Before |
| 5/2/2021 | RMH | Bradley,A | Promoted to active roster | | | Before |
| 5/2/2021 | RMH | Green | Placed on Injured List | | 4/27/2021 | Before |
| 5/8/2021 | AUR | Eovaldi | Promoted to active roster | | | Before |
| 5/8/2021 | AUR | Reyes,A | Promoted to active roster | | | Before |
| 5/8/2021 | AUR | Slegers | Demoted to reserve roster | | | Before |
| 5/8/2021 | AUR | Woodruff | Demoted to reserve roster | | | Before |
| 5/8/2021 | HOL | Cueto | Demoted to reserve roster | | | Before |
| 5/8/2021 | HOL | Urias,J | Activated from Injured List | | | Before |
| 5/10/2021 | CUY | Anderson,Ty | Acquired via trade | NHP | | After |
| 5/10/2021 | CUY | Holt | Traded away | NHP | | After |
| 5/10/2021 | CUY | Minter | Traded away | NHP | | After |
| 5/11/2021 | AUR | Eovaldi | Demoted to reserve roster | | | Before |
| 5/11/2021 | AUR | Jansen,D | Promoted to active roster | | | Before |
| 5/11/2021 | AUR | Pina | Demoted to reserve roster | | | Before |
| 5/11/2021 | AUR | Woodruff | Promoted to active roster | | | Before |
| 5/11/2021 | CAL | Mills | Signed | | | Before |
| 5/11/2021 | CUY | Mercado | Promoted to active roster | | | Before |
| 5/11/2021 | HOL | Guzman,R | Promoted to active roster | | | Before |
| 5/11/2021 | HOL | Lopez,N | Demoted to reserve roster | | | Before |
| 5/11/2021 | RMH | Flowers | Activated from Injured List | | | Before |
| 5/11/2021 | RMH | Lopes,T | Demoted to reserve roster | | | Before |
| 5/14/2021 | AUR | Hoyt | Demoted to reserve roster | | | Before |
| 5/14/2021 | AUR | Slegers | Promoted to active roster | | | Before |
| 5/14/2021 | CAL | Mills | Demoted to reserve roster | | | Before |
| 5/14/2021 | PBL | Brantley | Placed on Injured List | | 5/7/2021 | Before |
| 5/14/2021 | PBL | Hernandez,J | Demoted to reserve roster | | | Before |
| 5/14/2021 | PBL | Stewart,DJ | Activated from Injured List | | | Before |
| 5/14/2021 | PBL | Tepera | Promoted to active roster | | | Before |
| 5/14/2021 | PRO | Berti | Activated from Injured List | | | Before |
| 5/14/2021 | PRO | Hearn | Promoted to active roster | | | Before |
| 5/14/2021 | PRO | Smith,R | Demoted to reserve roster | | | Before |
| 5/14/2021 | PRO | Tejeda | Demoted to reserve roster | | | Before |
| 5/17/2021 | AUR | Hoyt | Promoted to active roster | | | Before |
| 5/17/2021 | AUR | Slegers | Demoted to reserve roster | | | Before |
| 5/17/2021 | HOL | Barnes,A | Placed on Injured List | | 5/16/2021 | Before |
| 5/17/2021 | HOL | Contreras,WJ | Promoted to active roster | | | Before |
| 5/17/2021 | HOL | Farmer,K | Placed on Injured List | | 5/17/2021 | Before |
| 5/17/2021 | HOL | Lopez,N | Promoted to active roster | | | Before |
| 5/17/2021 | PRO | Berti | Activated from Injured List | | | Before |
| 5/17/2021 | PRO | Smith,R | Demoted to reserve roster | | | Before |
| 5/17/2021 | PRO | Tejeda | Demoted to reserve roster | | | Before |
| 5/17/2021 | PRO | Webb,J | Promoted to active roster | | | Before |
| 5/17/2021 | RMH | Bradley,A | Demoted to reserve roster | | | Before |
| 5/17/2021 | RMH | Green | Activated from Injured List | | | Before |
| 5/20/2021 | AUR | Hoyt | Demoted to reserve roster | | | Before |
| 5/20/2021 | AUR | Slegers | Promoted to active roster | | | Before |
| 5/22/2021 | AUR | Hoyt | Traded away | NDF | | After |
| 5/22/2021 | AUR | Matzek | Acquired via trade | NDF | | After |
| 5/22/2021 | AUR | Scott | Traded away | NDF | | After |
| 5/22/2021 | AUR | Story | Acquired via trade | NDF | | After |
| 5/22/2021 | AUR | Stratton | Acquired via trade | NDF | | After |
| 5/22/2021 | AUR | Velasquez | Traded away | NDF | | After |
| 5/22/2021 | CLE | Anderson,N | Acquired via trade | CUY | | After |
| 5/22/2021 | CLE | Braun | Acquired via trade | CUY | | After |
| 5/22/2021 | CLE | Edman | Traded away | CUY | | After |
| 5/22/2021 | CLE | Gonzalez,C | Traded away | CUY | | After |
| 5/22/2021 | CLE | Harvey,M | Acquired via trade | CUY | | After |
| 5/22/2021 | CLE | Lorenzen | Acquired via trade | CUY | | After |
| 5/22/2021 | CLE | Taylor,C | Acquired via trade | CUY | | After |
| 5/22/2021 | CLE | Yastrzemski | Traded away | CUY | | After |
| 5/22/2021 | CUY | Anderson,N | Traded away | CLE | | After |
| 5/22/2021 | CUY | Braun | Traded away | CLE | | After |
| 5/22/2021 | CUY | Edman | Acquired via trade | CLE | | After |
| 5/22/2021 | CUY | Gonzalez,C | Acquired via trade | CLE | | After |
| 5/22/2021 | CUY | Harvey,M | Traded away | CLE | | After |
| 5/22/2021 | CUY | Lorenzen | Traded away | CLE | | After |
| 5/22/2021 | CUY | Taylor,C | Traded away | CLE | | After |
| 5/22/2021 | CUY | Yastrzemski | Acquired via trade | CLE | | After |
| 5/23/2021 | AUR | Rios,E | Demoted to reserve roster | | | Before |
| 5/23/2021 | AUR | Slegers | Demoted to reserve roster | | | Before |
| 5/23/2021 | CLE | Fairbanks | Demoted to reserve roster | | | Before |
| 5/23/2021 | CLE | Kieboom | Promoted to active roster | | | Before |
| 5/23/2021 | CLE | Lorenzen | Demoted to reserve roster | | | Before |
| 5/23/2021 | CLE | Moore | Placed on Injured List | | 5/23/2021 | Before |
| 5/23/2021 | CUY | Cease | Promoted to active roster | | | Before |
| 5/23/2021 | CUY | Mercado | Demoted to reserve roster | | | Before |
| 5/23/2021 | CUY | Pearson | Promoted to active roster | | | Before |
| 5/23/2021 | HOL | Casali | Activated from Injured List | | | Before |
| 5/23/2021 | HOL | Ruiz,K | Demoted to reserve roster | | | Before |
| 5/23/2021 | PBL | Brantley | Activated from Injured List | | | Before |
| 5/23/2021 | PBL | Hatch | Demoted to reserve roster | | | Before |
| 5/23/2021 | PBL | Hernandez,J | Promoted to active roster | | | Before |
| 5/23/2021 | PBL | Sierra | Demoted to reserve roster | | | Before |
| 5/23/2021 | PBL | Smith,B | Promoted to active roster | | | Before |
| 5/23/2021 | PBL | Tepera | Demoted to reserve roster | | | Before |
| 5/25/2021 | CLE | Alfaro | Traded away | NDF | | After |
| 5/25/2021 | CLE | Braun | Traded away | NDF | | After |
| 5/25/2021 | CLE | Finnegan | Acquired via trade | NDF | | After |
| 5/25/2021 | CLE | Mejia,F | Traded away | NDF | | After |
| 5/25/2021 | CLE | Nola,Au | Acquired via trade | NDF | | After |
| 5/26/2021 | DUR | Castano | Activated from Injured List | | | Before |
| 5/26/2021 | DUR | Johnson,P | Demoted to reserve roster | | | Before |
| 5/26/2021 | PRO | Berti | Placed on Injured List | | 5/24/2021 | Before |
| 5/26/2021 | PRO | Tejeda | Promoted to active roster | | | Before |
| 5/29/2021 | AUR | Eovaldi | Promoted to active roster | | | Before |
| 5/29/2021 | AUR | Gausman | Demoted to reserve roster | | | Before |
| 5/29/2021 | AUR | Slegers | Promoted to active roster | | | Before |
| 5/29/2021 | AUR | Stratton | Demoted to reserve roster | | | Before |
| 5/29/2021 | CLE | Kieboom | Demoted to reserve roster | | | Before |
| 5/29/2021 | CLE | Mathisen | Promoted to active roster | | | Before |
| 5/29/2021 | OLL | Verlander | Demoted to reserve roster | | | Before |
| 5/29/2021 | OLL | Williams,Tr | Promoted to active roster | | | Before |
| 5/29/2021 | PRO | Hampson | Placed on Injured List | | 5/27/2021 | Before |
| 5/29/2021 | PRO | Oliva | Promoted to active roster | | | Before |
| 5/29/2021 | RMH | Dobnak | Placed on Injured List | | 5/28/2021 | Before |
| 5/29/2021 | RMH | Wilson,B | Promoted to active roster | | | Before |
| 6/1/2021 | AUR | Eovaldi | Demoted to reserve roster | | | Before |
| 6/1/2021 | AUR | Gausman | Promoted to active roster | | | Before |
| 6/1/2021 | CAL | Hernandez,D | Demoted to reserve roster | | | Before |
| 6/1/2021 | CAL | Mills | Promoted to active roster | | | Before |
| 6/1/2021 | HOL | Davis,Jo | Demoted to reserve roster | | | Before |
| 6/1/2021 | HOL | Farmer,K | Activated from Injured List | | | Before |
| 6/1/2021 | OLL | Smith,Do | Placed on Injured List | | 5/30/2021 | Before |
| 6/1/2021 | OLL | Ward | Promoted to active roster | | | Before |
| 6/1/2021 | RMH | Gibson | Promoted to active roster | | | Before |
| 6/1/2021 | RMH | Wilson,B | Demoted to reserve roster | | | Before |
| 6/4/2021 | HOL | Montgomery,J | Promoted to active roster | | | Before |
| 6/4/2021 | HOL | Walker,T | Demoted to reserve roster | | | Before |
| 6/7/2021 | CLE | Mathisen | Demoted to reserve roster | | | Before |
| 6/7/2021 | CLE | Moore | Activated from Injured List | | | Before |
| 6/7/2021 | OLL | Gonzalez,G | Promoted to active roster | | | Before |
| 6/7/2021 | OLL | Ryan | Demoted to reserve roster | | | Before |
| 6/7/2021 | OLL | Schwarber | Promoted to active roster | | | Before |
| 6/7/2021 | OLL | Straw | Demoted to reserve roster | | | Before |
| 6/7/2021 | PRO | Hampson | Activated from Injured List | | | Before |
| 6/7/2021 | PRO | Oliva | Demoted to reserve roster | | | Before |
| 6/7/2021 | RMH | Kikuchi | Demoted to reserve roster | | | Before |
| 6/7/2021 | RMH | Mize | Promoted to active roster | | | Before |
| 6/10/2021 | OLL | Sanchez,Y | Demoted to reserve roster | | | Before |
| 6/10/2021 | OLL | Smith,Do | Activated from Injured List | | | Before |
| 6/10/2021 | PBL | Brantley | Placed on Injured List | | 6/9/2021 | Before |
| 6/10/2021 | PBL | Sierra | Promoted to active roster | | | Before |
| 6/13/2021 | RMH | Gibson | Demoted to reserve roster | | | Before |
| 6/13/2021 | RMH | Kikuchi | Promoted to active roster | | | Before |
| 6/13/2021 | RMH | Mize | Demoted to reserve roster | | | Before |
| 6/13/2021 | RMH | Wilson,B | Promoted to active roster | | | Before |
| 6/19/2021 | AUR | Castro,W | Demoted to reserve roster | | | Before |
| 6/19/2021 | AUR | Eovaldi | Promoted to active roster | | | Before |
| 6/19/2021 | AUR | Javier | Demoted to reserve roster | | | Before |
| 6/19/2021 | AUR | Rios,E | Promoted to active roster | | | Before |
| 6/19/2021 | AUR | Slegers | Demoted to reserve roster | | | Before |
| 6/19/2021 | AUR | Stratton | Promoted to active roster | | | Before |
| 6/19/2021 | CUY | Kelly,M | Demoted to reserve roster | | | Before |
| 6/19/2021 | CUY | Plutko | Promoted to active roster | | | Before |
| 6/22/2021 | CLE | Fleming | Demoted to reserve roster | | | Before |
| 6/22/2021 | CLE | Smith,C | Promoted to active roster | | | Before |
| 6/22/2021 | HOL | Kemp,T | Placed on Injured List | | 6/20/2021 | Before |
| 6/22/2021 | HOL | Ruiz,K | Promoted to active roster | | | Before |
| 6/25/2021 | AUR | Eovaldi | Demoted to reserve roster | | | Before |
| 6/25/2021 | AUR | Javier | Promoted to active roster | | | Before |
| 6/25/2021 | AUR | Slegers | Promoted to active roster | | | Before |
| 6/25/2021 | AUR | Stratton | Demoted to reserve roster | | | Before |
| 6/25/2021 | RMH | Dobnak | Activated from Injured List | | | Before |
| 6/25/2021 | RMH | Wilson,B | Demoted to reserve roster | | | Before |
| 6/28/2021 | AUR | Slegers | Demoted to reserve roster | | | Before |
| 6/28/2021 | AUR | Stratton | Promoted to active roster | | | Before |
| 6/28/2021 | RMH | Flowers | Placed on Injured List | | 6/27/2021 | Before |
| 6/28/2021 | RMH | Lopes,T | Promoted to active roster | | | Before |
| 6/30/2021 | AUR | Holland,G | Acquired via trade | RMH | | After |
| 6/30/2021 | AUR | Lamb | Traded away | RMH | | After |
| 6/30/2021 | AUR | Quinn | Traded away | RMH | | After |
| 6/30/2021 | AUR | Stratton | Traded away | RMH | | After |
| 6/30/2021 | RMH | Holland,G | Traded away | AUR | | After |
| 6/30/2021 | RMH | Lamb | Acquired via trade | AUR | | After |
| 6/30/2021 | RMH | Quinn | Acquired via trade | AUR | | After |
| 6/30/2021 | RMH | Stratton | Acquired via trade | AUR | | After |
| 7/1/2021 | AUR | Graveman | Promoted to active roster | | | Before |
| 7/1/2021 | AUR | Taylor,Bl | Placed on Injured List | | 6/30/2021 | Before |
| 7/1/2021 | CCC | Toussaint | Promoted to active roster | | | Before |
| 7/1/2021 | CCC | Urquidy | Demoted to reserve roster | | | Before |
| 7/1/2021 | DUR | Arozarena | Demoted to reserve roster | | | Before |
| 7/1/2021 | DUR | Encarnacion | Promoted to active roster | | | Before |
| 7/1/2021 | DUR | Gamel | Placed on Injured List | | 6/28/2021 | Before |
| 7/1/2021 | DUR | Murphy,JR | Demoted to reserve roster | | | Before |
| 7/1/2021 | DUR | Stephenson,T | Promoted to active roster | | | Before |
| 7/1/2021 | DUR | Zimmer,B | Promoted to active roster | | | Before |
| 7/1/2021 | PRO | Berti | Activated from Injured List | | | Before |
| 7/1/2021 | PRO | Tejeda | Demoted to reserve roster | | | Before |
| 7/4/2021 | CUY | Engel | Placed on Injured List | | 7/4/2021 | Before |
| 7/4/2021 | CUY | Mercado | Promoted to active roster | | | Before |
| 7/4/2021 | PBL | Cody | Promoted to active roster | | | Before |
| 7/4/2021 | PBL | Hatch | Promoted to active roster | | | Before |
| 7/4/2021 | PBL | Hudson,Dak | Demoted to reserve roster | | | Before |
| 7/4/2021 | PBL | Smith,B | Demoted to reserve roster | | | Before |
| 7/7/2021 | HOL | Kemp,T | Activated from Injured List | | | Before |
| 7/7/2021 | HOL | Ruiz,K | Demoted to reserve roster | | | Before |
| 7/10/2021 | AUR | Castro,W | Promoted to active roster | | | Before |
| 7/10/2021 | AUR | Javier | Demoted to reserve roster | | | Before |
| 7/10/2021 | AUR | Rios,E | Demoted to reserve roster | | | Before |
| 7/10/2021 | AUR | Slegers | Promoted to active roster | | | Before |
| 7/10/2021 | HOL | Barnes,A | Activated from Injured List | | | Before |
| 7/10/2021 | HOL | Contreras,WJ | Demoted to reserve roster | | | Before |
| 7/10/2021 | PBL | Brantley | Activated from Injured List | | | Before |
| 7/10/2021 | PBL | Sierra | Demoted to reserve roster | | | Before |
| 7/12/2021 | CLE | Apostel | Traded away | OLL | | After |
| 7/12/2021 | CLE | Gonzales | Acquired via trade | OLL | | After |
| 7/12/2021 | CLE | Harvey,M | Traded away | OLL | | After |
| 7/12/2021 | CLE | Howard,Sp | Traded away | OLL | | After |
| 7/12/2021 | CLE | Ryan | Acquired via trade | OLL | | After |
| 7/12/2021 | CLE | Sanchez,Y | Acquired via trade | OLL | | After |
| 7/12/2021 | OLL | Apostel | Acquired via trade | CLE | | After |
| 7/12/2021 | OLL | Gonzales | Traded away | CLE | | After |
| 7/12/2021 | OLL | Harvey,M | Acquired via trade | CLE | | After |
| 7/12/2021 | OLL | Howard,Sp | Acquired via trade | CLE | | After |
| 7/12/2021 | OLL | Ryan | Traded away | CLE | | After |
| 7/12/2021 | OLL | Sanchez,J | Acquired via trade | NHP | | After |
| 7/12/2021 | OLL | Sanchez,Y | Traded away | CLE | | After |
| 7/12/2021 | OLL | Smith,Do | Traded away | NHP | | After |
| 7/13/2021 | AUR | Bundy | Demoted to reserve roster | | | Before |
| 7/13/2021 | AUR | Bundy | Promoted to active roster | | | Before |
| 7/13/2021 | AUR | Castro,W | Demoted to reserve roster | | | Before |
| 7/13/2021 | AUR | Javier | Promoted to active roster | | | Before |
| 7/13/2021 | AUR | Rios,E | Promoted to active roster | | | Before |
| 7/13/2021 | AUR | Slegers | Demoted to reserve roster | | | Before |
| 7/13/2021 | CLE | Fairbanks | Promoted to active roster | | | Before |
| 7/13/2021 | CLE | Gonzales | Demoted to reserve roster | | | Before |
| 7/13/2021 | CLE | Gonzales | Promoted to active roster | | | Before |
| 7/13/2021 | CLE | Kintzler | Placed on Injured List | | 7/8/2021 | Before |
| 7/13/2021 | CLE | Smith,C | Demoted to reserve roster | | | Before |
| 7/13/2021 | OLL | Howard,Sp | Promoted to active roster | | | Before |
| 7/13/2021 | OLL | Vogelbach | Promoted to active roster | | | Before |
| 7/13/2021 | PRO | Hernandez,El | Demoted to reserve roster | | | Before |
| 7/13/2021 | PRO | Quantrill | Promoted to active roster | | | Before |
| 7/15/2021 | CAL | Baez,J | Traded away | DUR | | After |
| 7/15/2021 | CAL | Barnes,M | Traded away | TOR | | After |
| 7/15/2021 | CAL | Chapman,A | Traded away | DUR | | After |
| 7/15/2021 | CAL | Darvish | Acquired via trade | DUR | | After |
| 7/15/2021 | CAL | Gonzalez,V | Acquired via trade | TOR | | After |
| 7/15/2021 | CAL | Hand | Acquired via trade | LKE | | After |
| 7/15/2021 | CAL | Jansen,K | Traded away | TOR | | After |
| 7/15/2021 | CAL | Kemp,M | Traded away | DUR | | After |
| 7/15/2021 | CAL | Kratz | Traded away | TOR | | After |
| 7/15/2021 | CAL | Marquez,B | Traded away | DUR | | After |
| 7/15/2021 | CAL | Mills | Traded away | TOR | | After |
| 7/15/2021 | CAL | Pederson | Traded away | LKE | | After |
| 7/15/2021 | CAL | Porcello | Acquired via trade | TOR | | After |
| 7/15/2021 | CAL | Staumont | Acquired via trade | TOR | | After |
| 7/15/2021 | DUR | Baez,J | Acquired via trade | CAL | | After |
| 7/15/2021 | DUR | Chapman,A | Acquired via trade | CAL | | After |
| 7/15/2021 | DUR | Darvish | Traded away | CAL | | After |
| 7/15/2021 | DUR | Kemp,M | Acquired via trade | CAL | | After |
| 7/15/2021 | DUR | Marquez,B | Acquired via trade | CAL | | After |
| 7/16/2021 | AUR | Castro,W | Promoted to active roster | | | Before |
| 7/16/2021 | AUR | Jansen,D | Demoted to reserve roster | | | Before |
| 7/16/2021 | AUR | Maeda | Demoted to reserve roster | | | Before |
| 7/16/2021 | AUR | Pina | Promoted to active roster | | | Before |
| 7/16/2021 | CAL | Buxton | Placed on Injured List | | 7/14/2021 | Before |
| 7/16/2021 | CAL | Gonzalez,V | Promoted to active roster | | | Before |
| 7/16/2021 | CAL | Laureano | Promoted to active roster | | | Before |
| 7/16/2021 | CAL | Porcello | Demoted to reserve roster | | | Before |
| 7/16/2021 | DUR | Baez,J | Promoted to active roster | | | Before |
| 7/16/2021 | DUR | Chisholm | Demoted to reserve roster | | | Before |
| 7/16/2021 | DUR | Kemp,M | Promoted to active roster | | | Before |
| 7/16/2021 | DUR | Machin | Demoted to reserve roster | | | Before |
| 7/16/2021 | DUR | Machin | Promoted to active roster | | | Before |
| 7/16/2021 | DUR | Zimmer,B | Demoted to reserve roster | | | Before |
| 7/16/2021 | HOL | Loaisiga | Demoted to reserve roster | | | Before |
| 7/16/2021 | HOL | Skubal | Promoted to active roster | | | Before |
| 7/16/2021 | RMH | Flowers | Activated from Injured List | | | Before |
| 7/16/2021 | RMH | Freeland | Demoted to reserve roster | | | Before |
| 7/18/2021 | CAL | Piscotty | Acquired via trade | HOL | | After |
| 7/18/2021 | CAL | Reyes,F | Traded away | HOL | | After |
| 7/18/2021 | CAL | Shaw,T | Acquired via trade | HOL | | After |
| 7/18/2021 | CAL | Suero | Acquired via trade | HOL | | After |
| 7/18/2021 | CAL | Tapia,R | Acquired via trade | HOL | | After |
| 7/18/2021 | CAL | Turnbull | Acquired via trade | HOL | | After |
| 7/18/2021 | CLE | Alonso | Traded away | LKE | | After |
| 7/18/2021 | CLE | Beaty | Traded away | LKE | | After |
| 7/18/2021 | CLE | Castillo,L | Traded away | LKE | | After |
| 7/18/2021 | CLE | Davies | Acquired via trade | LKE | | After |
| 7/18/2021 | CLE | Fleming | Traded away | LKE | | After |
| 7/18/2021 | CLE | Jeffress | Acquired via trade | LKE | | After |
| 7/18/2021 | CLE | Keuchel | Acquired via trade | LKE | | After |
| 7/18/2021 | CLE | Lorenzen | Traded away | LKE | | After |
| 7/18/2021 | CLE | McKinney | Traded away | LKE | | After |
| 7/18/2021 | CLE | Ryan | Traded away | LKE | | After |
| 7/18/2021 | CLE | Sanchez,Y | Traded away | LKE | | After |
| 7/18/2021 | CUY | Castano | Acquired via trade | DUR | | After |
| 7/18/2021 | CUY | Diaz,I | Traded away | DUR | | After |
| 7/18/2021 | CUY | Foster | Acquired via trade | DUR | | After |
| 7/18/2021 | CUY | Kemp,M | Acquired via trade | DUR | | After |
| 7/18/2021 | CUY | Murphy,JR | Acquired via trade | DUR | | After |
| 7/18/2021 | CUY | Plutko | Traded away | DUR | | After |
| 7/18/2021 | CUY | Senzel | Traded away | DUR | | After |
| 7/18/2021 | CUY | Tomlin | Traded away | DUR | | After |
| 7/18/2021 | DUR | Castano | Traded away | CUY | | After |
| 7/18/2021 | DUR | Diaz,I | Acquired via trade | CUY | | After |
| 7/18/2021 | DUR | Foster | Traded away | CUY | | After |
| 7/18/2021 | DUR | Kemp,M | Traded away | CUY | | After |
| 7/18/2021 | DUR | Murphy,JR | Traded away | CUY | | After |
| 7/18/2021 | DUR | Plutko | Acquired via trade | CUY | | After |
| 7/18/2021 | DUR | Senzel | Acquired via trade | CUY | | After |
| 7/18/2021 | DUR | Tomlin | Acquired via trade | CUY | | After |
| 7/18/2021 | HOL | Farmer,K | Traded away | HAV | | After |
| 7/18/2021 | HOL | Hale | Acquired via trade | HAV | | After |
| 7/18/2021 | HOL | Piscotty | Traded away | CAL | | After |
| 7/18/2021 | HOL | Reyes,F | Acquired via trade | CAL | | After |
| 7/18/2021 | HOL | Shaw,T | Traded away | CAL | | After |
| 7/18/2021 | HOL | Suero | Traded away | CAL | | After |
| 7/18/2021 | HOL | Tapia,R | Traded away | CAL | | After |
| 7/18/2021 | HOL | Turnbull | Traded away | CAL | | After |
| 7/18/2021 | OLL | Jefferies | Acquired via trade | NHP | | After |
| 7/18/2021 | OLL | Santander | Traded away | NHP | | After |
| 7/19/2021 | AUR | Graveman | Demoted to reserve roster | | | Before |
| 7/19/2021 | AUR | Maeda | Promoted to active roster | | | Before |
| 7/19/2021 | CAL | Astudillo | Demoted to reserve roster | | | Before |
| 7/19/2021 | CAL | Astudillo | Promoted to active roster | | | Before |
| 7/19/2021 | CAL | Chirinos,R | Demoted to reserve roster | | | Before |
| 7/19/2021 | CAL | Gonzalez,V | Promoted to active roster | | | Before |
| 7/19/2021 | CAL | Hill,R | Demoted to reserve roster | | | Before |
| 7/19/2021 | CAL | Laureano | Promoted to active roster | | | Before |
| 7/19/2021 | CAL | Mathis | Demoted to reserve roster | | | Before |
| 7/19/2021 | CAL | Mathis | Promoted to active roster | | | Before |
| 7/19/2021 | CAL | Mathis | Promoted to active roster | | | Before |
| 7/19/2021 | CAL | Piscotty | Demoted to reserve roster | | | Before |
| 7/19/2021 | CAL | Porcello | Demoted to reserve roster | | | Before |
| 7/19/2021 | CAL | Shaw,T | Demoted to reserve roster | | | Before |
| 7/19/2021 | CAL | Staumont | Demoted to reserve roster | | | Before |
| 7/19/2021 | CLE | Antone | Demoted to reserve roster | | | Before |
| 7/19/2021 | CLE | Baragar | Demoted to reserve roster | | | Before |
| 7/19/2021 | CLE | Judge | Demoted to reserve roster | | | Before |
| 7/19/2021 | CUY | Kelly,M | Promoted to active roster | | | Before |
| 7/19/2021 | CUY | Murphy,JR | Promoted to active roster | | | Before |
| 7/19/2021 | CUY | Pearson | Demoted to reserve roster | | | Before |
| 7/19/2021 | DUR | Lugo,S | Promoted to active roster | | | Before |
| 7/19/2021 | DUR | Paredes,E | Demoted to reserve roster | | | Before |
| 7/19/2021 | HOL | Davis,Jo | Promoted to active roster | | | Before |
| 7/19/2021 | HOL | Hale | Promoted to active roster | | | Before |
| 7/19/2021 | HOL | Kirilloff | Promoted to active roster | | | Before |
| 7/19/2021 | HOL | Patino | Promoted to active roster | | | Before |
| 7/19/2021 | HOL | Walker,T | Promoted to active roster | | | Before |
| 7/19/2021 | OLL | Straw | Promoted to active roster | | | Before |
| 7/22/2021 | AUR | Rios,E | Demoted to reserve roster | | | Before |
| 7/22/2021 | AUR | Slegers | Promoted to active roster | | | Before |
| 7/22/2021 | CLE | Antone | Promoted to active roster | | | Before |
| 7/22/2021 | CLE | Martin,B | Demoted to reserve roster | | | Before |
| 7/22/2021 | CLE | Mathisen | Promoted to active roster | | | Before |
| 7/22/2021 | RMH | Calhoun,W | Placed on Injured List | | 7/15/2021 | Before |
| 7/22/2021 | RMH | Freeland | Promoted to active roster | | | Before |
| 7/22/2021 | RMH | Quinn | Promoted to active roster | | | Before |
| 7/22/2021 | RMH | Walsh | Demoted to reserve roster | | | Before |
| 7/25/2021 | AUR | Davis,JD | Demoted to reserve roster | | | Before |
| 7/25/2021 | AUR | McMahon | Demoted to reserve roster | | | Before |
| 7/25/2021 | AUR | Rios,E | Promoted to active roster | | | Before |
| 7/25/2021 | AUR | Taylor,Bl | Activated from Injured List | | | Before |
| 7/28/2021 | AUR | Davis,JD | Promoted to active roster | | | Before |
| 7/28/2021 | AUR | Slegers | Demoted to reserve roster | | | Before |
| 7/28/2021 | CAL | Smyly | Demoted to reserve roster | | | Before |
| 7/28/2021 | CAL | Staumont | Promoted to active roster | | | Before |
| 7/28/2021 | CLE | Brogdon | Promoted to active roster | | | Before |
| 7/28/2021 | CLE | Hahn | Demoted to reserve roster | | | Before |
| 7/28/2021 | CLE | Kintzler | Activated from Injured List | | | Before |
| 7/28/2021 | CLE | Kintzler | Demoted to reserve roster | | | Before |
| 7/28/2021 | CLE | Martin,C | Demoted to reserve roster | | | Before |
| 7/28/2021 | CLE | Whitley | Promoted to active roster | | | Before |
| 7/28/2021 | PBL | O'Hearn | Promoted to active roster | | | Before |
| 7/28/2021 | PBL | Stewart,DJ | Demoted to reserve roster | | | Before |
| 7/31/2021 | AUR | Davis,JD | Demoted to reserve roster | | | Before |
| 7/31/2021 | AUR | Jansen,D | Promoted to active roster | | | Before |
| 7/31/2021 | AUR | Pina | Demoted to reserve roster | | | Before |
| 7/31/2021 | AUR | Slegers | Promoted to active roster | | | Before |
| 7/31/2021 | CCC | Matz | Demoted to reserve roster | | | Before |
| 7/31/2021 | CCC | Miley | Promoted to active roster | | | Before |
| 7/31/2021 | CUY | Engel | Activated from Injured List | | | Before |
| 7/31/2021 | CUY | Kelly,M | Demoted to reserve roster | | | Before |
| 7/31/2021 | CUY | Mercado | Demoted to reserve roster | | | Before |
| 7/31/2021 | CUY | Pearson | Promoted to active roster | | | Before |
| 7/31/2021 | DCM | Paxton | Promoted to active roster | | | Before |
| 7/31/2021 | DCM | Weems | Promoted to active roster | | | Before |
| 7/31/2021 | PBL | Gonsolin | Demoted to reserve roster | | | Before |
| 7/31/2021 | PBL | Hudson,Dak | Promoted to active roster | | | Before |
| 7/31/2021 | RMH | Calhoun,W | Activated from Injured List | | | Before |
| 7/31/2021 | RMH | Lopes,T | Placed on Injured List | | 7/31/2021 | Before |
| 7/31/2021 | RMH | Lopez,P | Demoted to reserve roster | | | Before |
| 7/31/2021 | RMH | Quinn | Demoted to reserve roster | | | Before |
| 7/31/2021 | RMH | Robertson | Promoted to active roster | | | Before |
| 7/31/2021 | RMH | Walsh | Promoted to active roster | | | Before |
| 8/3/2021 | DUR | Encarnacion | Demoted to reserve roster | | | Before |
| 8/3/2021 | DUR | Gamel | Activated from Injured List | | | Before |
| 8/3/2021 | OLL | Williams,Tr | Demoted to reserve roster | | | Before |
| 8/3/2021 | OLL | Ynoa | Promoted to active roster | | | Before |
| 8/3/2021 | RMH | Quinn | Promoted to active roster | | | Before |
| 8/3/2021 | RMH | Walsh | Demoted to reserve roster | | | Before |
| 8/6/2021 | HOL | Knebel | Promoted to active roster | | | Before |
| 8/6/2021 | HOL | Topa | Demoted to reserve roster | | | Before |
| 8/9/2021 | AUR | Davis,JD | Promoted to active roster | | | Before |
| 8/9/2021 | AUR | Rios,E | Demoted to reserve roster | | | Before |
| 8/9/2021 | CCC | Cordero,J | Promoted to active roster | | | Before |
| 8/9/2021 | CCC | Magill | Promoted to active roster | | | Before |
| 8/9/2021 | CCC | Miley | Placed on Injured List | | 8/8/2021 | Before |
| 8/9/2021 | CCC | Woodford | Demoted to reserve roster | | | Before |
| 8/9/2021 | PRO | Barnes,J | Promoted to active roster | | | Before |
| 8/9/2021 | PRO | Webb,J | Demoted to reserve roster | | | Before |
| 8/9/2021 | RMH | Arroyo | Demoted to reserve roster | | | Before |
| 8/9/2021 | RMH | Gibson | Promoted to active roster | | | Before |
| 8/9/2021 | RMH | Lopez,P | Promoted to active roster | | | Before |
| 8/9/2021 | RMH | Quinn | Demoted to reserve roster | | | Before |
| 8/12/2021 | AUR | Castro,W | Demoted to reserve roster | | | Before |
| 8/12/2021 | AUR | McMahon | Promoted to active roster | | | Before |
| 8/12/2021 | AUR | Rios,E | Promoted to active roster | | | Before |
| 8/12/2021 | AUR | Slegers | Demoted to reserve roster | | | Before |
| 8/12/2021 | CAL | Buxton | Activated from Injured List | | | Before |
| 8/12/2021 | CAL | Laureano | Demoted to reserve roster | | | Before |
| 8/15/2021 | AUR | Castro,W | Promoted to active roster | | | Before |
| 8/15/2021 | AUR | Davis,JD | Demoted to reserve roster | | | Before |
| 8/15/2021 | AUR | Davis,JD | Promoted to active roster | | | Before |
| 8/15/2021 | AUR | McMahon | Demoted to reserve roster | | | Before |
| 8/15/2021 | AUR | Rios,E | Demoted to reserve roster | | | Before |
| 8/15/2021 | AUR | Rios,E | Promoted to active roster | | | Before |
| 8/15/2021 | AUR | Rios,E | Demoted to reserve roster | | | Before |
| 8/15/2021 | AUR | Slegers | Promoted to active roster | | | Before |
| 8/15/2021 | CCC | Cervelli | Placed on Injured List | | 8/14/2021 | Before |
| 8/15/2021 | CCC | Schreiber | Promoted to active roster | | | Before |
| 8/15/2021 | HOL | Donaldson | Placed on Injured List | | 8/13/2021 | Before |
| 8/15/2021 | HOL | Ruiz,K | Promoted to active roster | | | Before |
| 8/15/2021 | PRO | Sheffield | Placed on Injured List | | 8/13/2021 | Before |
| 8/15/2021 | PRO | Webb,L | Promoted to active roster | | | Before |
| 8/15/2021 | RMH | Gibson | Demoted to reserve roster | | | Before |
| 8/15/2021 | RMH | Lopes,T | Activated from Injured List | | | Before |
| 8/18/2021 | PBL | Castellani | Demoted to reserve roster | | | Before |
| 8/18/2021 | PBL | Gonsolin | Promoted to active roster | | | Before |
| 8/18/2021 | PRO | Parker | Demoted to reserve roster | | | Before |
| 8/18/2021 | PRO | Reid-Foley | Promoted to active roster | | | Before |
| 8/18/2021 | PRO | Romano,J | Demoted to reserve roster | | | Before |
| 8/18/2021 | PRO | Smith,R | Promoted to active roster | | | Before |
| 8/21/2021 | AUR | Rios,E | Promoted to active roster | | | Before |
| 8/21/2021 | AUR | Slegers | Demoted to reserve roster | | | Before |
| 8/21/2021 | HOL | Allen,L | Promoted to active roster | | | Before |
| 8/21/2021 | HOL | Graterol | Demoted to reserve roster | | | Before |
| 8/21/2021 | PBL | Gallegos | Demoted to reserve roster | | | Before |
| 8/21/2021 | PBL | Hernandez,T | Placed on Injured List | | 8/21/2021 | Before |
| 8/21/2021 | PBL | Sierra | Promoted to active roster | | | Before |
| 8/21/2021 | PBL | Stewart,DJ | Promoted to active roster | | | Before |
| 8/24/2021 | AUR | Davis,JD | Demoted to reserve roster | | | Before |
| 8/24/2021 | AUR | Slegers | Promoted to active roster | | | Before |
| 8/27/2021 | AUR | Munoz | Promoted to active roster | | | Before |
| 8/27/2021 | AUR | Slegers | Demoted to reserve roster | | | Before |
| 8/27/2021 | CLE | Brogdon | Demoted to reserve roster | | | Before |
| 8/27/2021 | CLE | Fairbanks | Demoted to reserve roster | | | Before |
| 8/27/2021 | CLE | Hahn | Promoted to active roster | | | Before |
| 8/27/2021 | CLE | Martin,C | Promoted to active roster | | | Before |
| 8/27/2021 | OLL | Inciarte | Promoted to active roster | | | Before |
| 8/27/2021 | OLL | Junis | Promoted to active roster | | | Before |
| 8/27/2021 | OLL | Moustakas | Placed on Injured List | | 8/27/2021 | Before |
| 8/27/2021 | OLL | Ynoa | Placed on Injured List | | 8/25/2021 | Before |
| 8/30/2021 | AUR | Munoz | Demoted to reserve roster | | | Before |
| 8/30/2021 | AUR | Slegers | Promoted to active roster | | | Before |
| 8/30/2021 | CAL | Hill,R | Promoted to active roster | | | Before |
| 8/30/2021 | CAL | Sanchez,S | Demoted to reserve roster | | | Before |
| 8/30/2021 | CUY | Kelly,M | Promoted to active roster | | | Before |
| 8/30/2021 | CUY | Murphy,JR | Demoted to reserve roster | | | Before |
| 8/30/2021 | PRO | Hoskins | Placed on Injured List | | 8/27/2021 | Before |
| 8/30/2021 | PRO | Nottingham | Promoted to active roster | | | Before |
| 8/30/2021 | RMH | Dobnak | Demoted to reserve roster | | | Before |
| 8/30/2021 | RMH | Mize | Promoted to active roster | | | Before |
| 9/2/2021 | OLL | Apostel | Promoted to active roster | | | Before |
| 9/2/2021 | OLL | Vogelbach | Placed on Injured List | | 9/2/2021 | Before |
| 9/5/2021 | AUR | Bradley,J | Demoted to reserve roster | | | Before |
| 9/5/2021 | AUR | Castro,W | Demoted to reserve roster | | | Before |
| 9/5/2021 | AUR | Cron,CJ | Promoted to active roster | | | Before |
| 9/5/2021 | AUR | Davis,JD | Promoted to active roster | | | Before |
| 9/5/2021 | AUR | Eovaldi | Promoted to active roster | | | Before |
| 9/5/2021 | AUR | Graveman | Promoted to active roster | | | Before |
| 9/5/2021 | AUR | Jansen,D | Demoted to reserve roster | | | Before |
| 9/5/2021 | AUR | Maeda | Demoted to reserve roster | | | Before |
| 9/5/2021 | AUR | McMahon | Promoted to active roster | | | Before |
| 9/5/2021 | AUR | Moreland | Demoted to reserve roster | | | Before |
| 9/5/2021 | AUR | Munoz | Promoted to active roster | | | Before |
| 9/5/2021 | AUR | Norris | Demoted to reserve roster | | | Before |
| 9/5/2021 | AUR | Ohtani | Promoted to active roster | | | Before |
| 9/5/2021 | AUR | Pina | Promoted to active roster | | | Before |
| 9/5/2021 | AUR | Rios,E | Demoted to reserve roster | | | Before |
| 9/5/2021 | AUR | Taylor,Bl | Demoted to reserve roster | | | Before |
| 9/5/2021 | AUR | Wright | Promoted to active roster | | | Before |
| 9/5/2021 | CAL | Arraez | Demoted to reserve roster | | | Before |
| 9/5/2021 | CAL | Gray,S | Demoted to reserve roster | | | Before |
| 9/5/2021 | CAL | Hill,R | Demoted to reserve roster | | | Before |
| 9/5/2021 | CAL | Laureano | Promoted to active roster | | | Before |
| 9/5/2021 | CAL | Porcello | Promoted to active roster | | | Before |
| 9/5/2021 | CAL | Shaw,T | Promoted to active roster | | | Before |
| 9/5/2021 | CAL | Tapia,R | Placed on Injured List | | 9/3/2021 | Before |
| 9/5/2021 | CAL | Weaver | Promoted to active roster | | | Before |
| 9/5/2021 | PBL | Diaz,El | Placed on Injured List | | 9/3/2021 | Before |
| 9/5/2021 | PBL | Hernandez,T | Activated from Injured List | | | Before |
| 9/5/2021 | PBL | Hosmer | Demoted to reserve roster | | | Before |
| 9/5/2021 | PBL | Nido | Promoted to active roster | | | Before |
| 9/8/2021 | CAL | Astudillo | Promoted to active roster | | | Before |
| 9/8/2021 | CAL | Chapman,M | Demoted to reserve roster | | | Before |
| 9/8/2021 | RMH | Chavis | Demoted to reserve roster | | | Before |
| 9/8/2021 | RMH | Dobnak | Demoted to reserve roster | | | Before |
| 9/8/2021 | RMH | Dobnak | Promoted to active roster | | | Before |
| 9/8/2021 | RMH | Dobnak | Promoted to active roster | | | Before |
| 9/8/2021 | RMH | Mize | Demoted to reserve roster | | | Before |
| 9/8/2021 | RMH | Walsh | Promoted to active roster | | | Before |
| 9/11/2021 | AUR | Bundy | Demoted to reserve roster | | | Before |
| 9/11/2021 | AUR | Lopez,R | Promoted to active roster | | | Before |
| 9/11/2021 | AUR | Wood | Promoted to active roster | | | Before |
| 9/11/2021 | AUR | Woodruff | Demoted to reserve roster | | | Before |
| 9/11/2021 | CAL | Buxton | Demoted to reserve roster | | | Before |
| 9/11/2021 | CAL | Piscotty | Promoted to active roster | | | Before |