| Transactions |
| Date | Team | Player | Type | OthTm | EffDate | When |
| 4/8/2021 | DRB | Britton | Demoted to reserve roster | | | Before |
| 4/8/2021 | DRB | Miller,A | Demoted to reserve roster | | | Before |
| 4/8/2021 | DRB | Roe | Promoted to active roster | | | Before |
| 4/8/2021 | DRB | Romano,S | Promoted to active roster | | | Before |
| 4/8/2021 | NHP | Locastro | Demoted to reserve roster | | | Before |
| 4/8/2021 | NHP | Smith,WM | Promoted to active roster | | | Before |
| 4/10/2021 | NDF | Andrus | Acquired via trade | DUR | | After |
| 4/10/2021 | NDF | Escobar | Traded away | DUR | | After |
| 4/10/2021 | NDF | Fowler | Traded away | DUR | | After |
| 4/10/2021 | NDF | Johnson,D | Acquired via trade | DUR | | After |
| 4/11/2021 | DRB | Britton | Promoted to active roster | | | Before |
| 4/11/2021 | DRB | Marisnick | Placed on Injured List | | 4/11/2021 | Before |
| 4/11/2021 | DRB | Miller,A | Demoted to reserve roster | | | Before |
| 4/11/2021 | DRB | Miller,A | Promoted to active roster | | | Before |
| 4/11/2021 | DRB | Romano,S | Demoted to reserve roster | | | Before |
| 4/11/2021 | DRB | Taylor,M | Promoted to active roster | | | Before |
| 4/11/2021 | NDF | Andrus | Demoted to reserve roster | | | Before |
| 4/11/2021 | NDF | Bummer | Placed on Injured List | | 4/8/2021 | Before |
| 4/11/2021 | NDF | Cobb | Placed on Injured List | | 4/9/2021 | Before |
| 4/11/2021 | NDF | Garcia,LH | Promoted to active roster | | | Before |
| 4/11/2021 | NDF | Ponce de Leon | Promoted to active roster | | | Before |
| 4/11/2021 | NDF | Urias,R | Promoted to active roster | | | Before |
| 4/11/2021 | PEA | McCullers | Placed on Injured List | | 4/8/2021 | Before |
| 4/11/2021 | PEA | Ponce | Promoted to active roster | | | Before |
| 4/11/2021 | SPR | McCutchen | Promoted to active roster | | | Before |
| 4/11/2021 | SPR | Pineda | Placed on Injured List | | 4/7/2021 | Before |
| 4/11/2021 | SPR | Robles,H | Promoted to active roster | | | Before |
| 4/11/2021 | SPR | Rojas,M | Placed on Injured List | | 4/10/2021 | Before |
| 4/11/2021 | TOR | Martinez,C | Promoted to active roster | | | Before |
| 4/11/2021 | TOR | Tropeano | Demoted to reserve roster | | | Before |
| 4/14/2021 | DRB | Castro,S | Demoted to reserve roster | | | Before |
| 4/14/2021 | DRB | Gonzalez,E | Promoted to active roster | | | Before |
| 4/14/2021 | HAV | Kendrick | Traded away | DUR | | After |
| 4/14/2021 | HAV | Shreve | Acquired via trade | DUR | | After |
| 4/14/2021 | PEA | Arauz | Promoted to active roster | | | Before |
| 4/14/2021 | PEA | Gimenez | Placed on Injured List | | 4/13/2021 | Before |
| 4/14/2021 | TOR | Long | Demoted to reserve roster | | | Before |
| 4/14/2021 | TOR | Strasburg | Promoted to active roster | | | Before |
| 4/14/2021 | TOR | Suarez,J | Demoted to reserve roster | | | Before |
| 4/14/2021 | TOR | Tropeano | Demoted to reserve roster | | | Before |
| 4/14/2021 | TOR | Tropeano | Promoted to active roster | | | Before |
| 4/14/2021 | TOR | Tropeano | Promoted to active roster | | | Before |
| 4/17/2021 | DRB | Anderson,I | Demoted to reserve roster | | | Before |
| 4/17/2021 | DRB | Miller,A | Promoted to active roster | | | Before |
| 4/17/2021 | DRB | Roe | Demoted to reserve roster | | | Before |
| 4/17/2021 | DRB | Stripling | Promoted to active roster | | | Before |
| 4/17/2021 | PEA | Fuentes | Placed on Injured List | | 4/15/2021 | Before |
| 4/17/2021 | PEA | Pujols | Promoted to active roster | | | Before |
| 4/17/2021 | TOR | Gonzalez,V | Promoted to active roster | | | Before |
| 4/17/2021 | TOR | Greiner | Demoted to reserve roster | | | Before |
| 4/17/2021 | TOR | Higashioka | Promoted to active roster | | | Before |
| 4/17/2021 | TOR | Martinez,C | Demoted to reserve roster | | | Before |
| 4/17/2021 | TOR | Suarez,J | Demoted to reserve roster | | | Before |
| 4/17/2021 | TOR | Suarez,J | Promoted to active roster | | | Before |
| 4/20/2021 | DRB | Anderson,I | Promoted to active roster | | | Before |
| 4/20/2021 | DRB | Castro,S | Promoted to active roster | | | Before |
| 4/20/2021 | DRB | Riley | Placed on Injured List | | 4/20/2021 | Before |
| 4/20/2021 | DRB | Stripling | Demoted to reserve roster | | | Before |
| 4/20/2021 | NHP | Alzolay | Placed on Injured List | | 4/20/2021 | Before |
| 4/20/2021 | NHP | Montas | Promoted to active roster | | | Before |
| 4/20/2021 | NHP | Musgrove | Placed on Injured List | | 4/19/2021 | Before |
| 4/20/2021 | NHP | Paddack | Promoted to active roster | | | Before |
| 4/20/2021 | WTB | Burrows | Promoted to active roster | | | Before |
| 4/20/2021 | WTB | Means | Placed on Injured List | | 4/18/2021 | Before |
| 4/23/2021 | DRB | Marisnick | Activated from Injured List | | | Before |
| 4/23/2021 | DRB | Taylor,M | Demoted to reserve roster | | | Before |
| 4/23/2021 | SPR | Gordon,A | Promoted to active roster | | | Before |
| 4/23/2021 | SPR | Pineda | Activated from Injured List | | | Before |
| 4/23/2021 | SPR | Robles,H | Demoted to reserve roster | | | Before |
| 4/23/2021 | SPR | Trevino | Placed on Injured List | | 4/23/2021 | Before |
| 4/23/2021 | TOR | Greiner | Promoted to active roster | | | Before |
| 4/23/2021 | TOR | Higashioka | Demoted to reserve roster | | | Before |
| 4/23/2021 | TOR | Keller,M | Demoted to reserve roster | | | Before |
| 4/23/2021 | TOR | Long | Promoted to active roster | | | Before |
| 4/23/2021 | TOR | Martinez,C | Promoted to active roster | | | Before |
| 4/23/2021 | TOR | Strasburg | Demoted to reserve roster | | | Before |
| 4/23/2021 | TOR | Suarez,J | Promoted to active roster | | | Before |
| 4/23/2021 | TOR | Tropeano | Demoted to reserve roster | | | Before |
| 4/26/2021 | DRB | Miller,A | Placed on Injured List | | 4/26/2021 | Before |
| 4/26/2021 | DRB | Roe | Promoted to active roster | | | Before |
| 4/26/2021 | NHP | Gardner | Placed on Injured List | | 4/26/2021 | Before |
| 4/26/2021 | NHP | Locastro | Promoted to active roster | | | Before |
| 4/29/2021 | DRB | Bailey,H | Promoted to active roster | | | Before |
| 4/29/2021 | DRB | Roe | Demoted to reserve roster | | | Before |
| 4/29/2021 | TOR | Keller,M | Promoted to active roster | | | Before |
| 4/29/2021 | TOR | Martinez,C | Demoted to reserve roster | | | Before |
| 4/29/2021 | TOR | Martinez,C | Promoted to active roster | | | Before |
| 4/29/2021 | TOR | Merryweather | Demoted to reserve roster | | | Before |
| 5/1/2021 | CED | Fisher | Acquired via trade | PBL | | After |
| 5/1/2021 | CED | Sierra | Traded away | PBL | | After |
| 5/2/2021 | CED | Choo | Placed on Injured List | | 4/29/2021 | Before |
| 5/2/2021 | CED | Fisher | Promoted to active roster | | | Before |
| 5/2/2021 | NHP | Alzolay | Activated from Injured List | | | Before |
| 5/2/2021 | NHP | Montas | Demoted to reserve roster | | | Before |
| 5/5/2021 | DRB | May,D | Demoted to reserve roster | | | Before |
| 5/5/2021 | DRB | Riley | Activated from Injured List | | | Before |
| 5/5/2021 | DRB | Stripling | Promoted to active roster | | | Before |
| 5/5/2021 | DRB | Taylor,M | Demoted to reserve roster | | | Before |
| 5/5/2021 | DRB | Taylor,M | Promoted to active roster | | | Before |
| 5/5/2021 | PEA | Arauz | Demoted to reserve roster | | | Before |
| 5/5/2021 | PEA | Gimenez | Activated from Injured List | | | Before |
| 5/5/2021 | PEA | McCullers | Activated from Injured List | | | Before |
| 5/5/2021 | PEA | Ponce | Demoted to reserve roster | | | Before |
| 5/5/2021 | TOR | Greiner | Demoted to reserve roster | | | Before |
| 5/5/2021 | TOR | Higashioka | Promoted to active roster | | | Before |
| 5/5/2021 | TOR | Martinez,C | Demoted to reserve roster | | | Before |
| 5/5/2021 | TOR | Merryweather | Promoted to active roster | | | Before |
| 5/5/2021 | TOR | Suarez,J | Demoted to reserve roster | | | Before |
| 5/5/2021 | TOR | Tropeano | Promoted to active roster | | | Before |
| 5/5/2021 | WTB | Burrows | Demoted to reserve roster | | | Before |
| 5/5/2021 | WTB | Means | Activated from Injured List | | | Before |
| 5/8/2021 | CED | Gallagher | Placed on Injured List | | 5/7/2021 | Before |
| 5/8/2021 | CED | Hedges | Promoted to active roster | | | Before |
| 5/8/2021 | DRB | Bailey,H | Demoted to reserve roster | | | Before |
| 5/8/2021 | DRB | May,D | Promoted to active roster | | | Before |
| 5/8/2021 | DRB | Maybin | Demoted to reserve roster | | | Before |
| 5/8/2021 | DRB | Miller,A | Activated from Injured List | | | Before |
| 5/8/2021 | DRB | Stripling | Demoted to reserve roster | | | Before |
| 5/8/2021 | DRB | Taylor,M | Demoted to reserve roster | | | Before |
| 5/8/2021 | DRB | Taylor,M | Promoted to active roster | | | Before |
| 5/8/2021 | PEA | Bishop | Promoted to active roster | | | Before |
| 5/8/2021 | PEA | Springer | Placed on Injured List | | 5/7/2021 | Before |
| 5/10/2021 | NHP | Anderson,Ty | Traded away | CUY | | After |
| 5/10/2021 | NHP | Holt | Acquired via trade | CUY | | After |
| 5/10/2021 | NHP | Minter | Acquired via trade | CUY | | After |
| 5/11/2021 | DRB | May,D | Demoted to reserve roster | | | Before |
| 5/11/2021 | DRB | Stripling | Promoted to active roster | | | Before |
| 5/11/2021 | NHP | Holt | Demoted to reserve roster | | | Before |
| 5/14/2021 | NHP | Gardner | Activated from Injured List | | | Before |
| 5/14/2021 | NHP | Locastro | Demoted to reserve roster | | | Before |
| 5/17/2021 | DRB | Anderson,I | Demoted to reserve roster | | | Before |
| 5/17/2021 | DRB | May,D | Promoted to active roster | | | Before |
| 5/17/2021 | SPR | Gordon,A | Demoted to reserve roster | | | Before |
| 5/17/2021 | SPR | McCutchen | Demoted to reserve roster | | | Before |
| 5/17/2021 | SPR | Rojas,M | Activated from Injured List | | | Before |
| 5/17/2021 | SPR | Trevino | Activated from Injured List | | | Before |
| 5/20/2021 | CED | Choo | Activated from Injured List | | | Before |
| 5/20/2021 | CED | Fisher | Demoted to reserve roster | | | Before |
| 5/20/2021 | DRB | Alberto | Placed on Injured List | | 5/20/2021 | Before |
| 5/20/2021 | DRB | Hechavarria | Promoted to active roster | | | Before |
| 5/20/2021 | PEA | Arauz | Promoted to active roster | | | Before |
| 5/20/2021 | PEA | Odor | Placed on Injured List | | 5/18/2021 | Before |
| 5/20/2021 | TOR | Andriese | Demoted to reserve roster | | | Before |
| 5/20/2021 | TOR | Gonzalez,V | Demoted to reserve roster | | | Before |
| 5/20/2021 | TOR | Greiner | Promoted to active roster | | | Before |
| 5/20/2021 | TOR | Higashioka | Demoted to reserve roster | | | Before |
| 5/20/2021 | TOR | Martinez,C | Promoted to active roster | | | Before |
| 5/20/2021 | TOR | Suarez,J | Promoted to active roster | | | Before |
| 5/22/2021 | HAV | Alvarado | Traded away | NDF | | After |
| 5/22/2021 | HAV | Beeks | Traded away | NDF | | After |
| 5/22/2021 | HAV | Cishek | Traded away | NDF | | After |
| 5/22/2021 | HAV | Cobb | Acquired via trade | NDF | | After |
| 5/22/2021 | HAV | Garcia,Ja | Acquired via trade | NDF | | After |
| 5/22/2021 | HAV | Greene | Traded away | NDF | | After |
| 5/22/2021 | HAV | Jimenez,J | Traded away | NDF | | After |
| 5/22/2021 | HAV | Mazza | Traded away | NDF | | After |
| 5/22/2021 | HAV | Ottavino | Traded away | NDF | | After |
| 5/22/2021 | HAV | Rooker | Traded away | NDF | | After |
| 5/22/2021 | HAV | Workman | Traded away | NDF | | After |
| 5/22/2021 | NDF | Alvarado | Acquired via trade | HAV | | After |
| 5/22/2021 | NDF | Beeks | Acquired via trade | HAV | | After |
| 5/22/2021 | NDF | Cishek | Acquired via trade | HAV | | After |
| 5/22/2021 | NDF | Cobb | Traded away | HAV | | After |
| 5/22/2021 | NDF | Garcia,Ja | Traded away | HAV | | After |
| 5/22/2021 | NDF | Greene | Acquired via trade | HAV | | After |
| 5/22/2021 | NDF | Hoyt | Acquired via trade | AUR | | After |
| 5/22/2021 | NDF | Jimenez,J | Acquired via trade | HAV | | After |
| 5/22/2021 | NDF | Matzek | Traded away | AUR | | After |
| 5/22/2021 | NDF | Mazza | Acquired via trade | HAV | | After |
| 5/22/2021 | NDF | Ottavino | Acquired via trade | HAV | | After |
| 5/22/2021 | NDF | Rooker | Acquired via trade | HAV | | After |
| 5/22/2021 | NDF | Scott | Acquired via trade | AUR | | After |
| 5/22/2021 | NDF | Story | Traded away | AUR | | After |
| 5/22/2021 | NDF | Stratton | Traded away | AUR | | After |
| 5/22/2021 | NDF | Velasquez | Acquired via trade | AUR | | After |
| 5/22/2021 | NDF | Workman | Acquired via trade | HAV | | After |
| 5/23/2021 | DRB | Anderson,I | Promoted to active roster | | | Before |
| 5/23/2021 | DRB | Avila | Demoted to reserve roster | | | Before |
| 5/23/2021 | DRB | Carrasco | Demoted to reserve roster | | | Before |
| 5/23/2021 | DRB | Maybin | Promoted to active roster | | | Before |
| 5/23/2021 | HAV | Cobb | Activated from Injured List | | | Before |
| 5/23/2021 | TOR | Andriese | Promoted to active roster | | | Before |
| 5/23/2021 | TOR | Gonzalez,V | Promoted to active roster | | | Before |
| 5/23/2021 | TOR | Suarez,J | Demoted to reserve roster | | | Before |
| 5/23/2021 | TOR | Tropeano | Demoted to reserve roster | | | Before |
| 5/25/2021 | NDF | Alfaro | Acquired via trade | CLE | | After |
| 5/25/2021 | NDF | Braun | Acquired via trade | CLE | | After |
| 5/25/2021 | NDF | Finnegan | Traded away | CLE | | After |
| 5/25/2021 | NDF | Mejia,F | Acquired via trade | CLE | | After |
| 5/25/2021 | NDF | Nola,Au | Traded away | CLE | | After |
| 5/26/2021 | NDF | Beeks | Demoted to reserve roster | | | Before |
| 5/26/2021 | NDF | Bell | Demoted to reserve roster | | | Before |
| 5/26/2021 | NDF | Bell | Promoted to active roster | | | Before |
| 5/26/2021 | NDF | Bummer | Activated from Injured List | | | Before |
| 5/26/2021 | NDF | Garcia,LH | Demoted to reserve roster | | | Before |
| 5/26/2021 | NDF | Hoyt | Promoted to active roster | | | Before |
| 5/26/2021 | NDF | Rooker | Demoted to reserve roster | | | Before |
| 5/26/2021 | NDF | Rooker | Promoted to active roster | | | Before |
| 5/26/2021 | NDF | Rooker | Promoted to active roster | | | Before |
| 5/26/2021 | NDF | Vogt | Promoted to active roster | | | Before |
| 5/26/2021 | NDF | Young,An | Demoted to reserve roster | | | Before |
| 5/26/2021 | PEA | Bishop | Demoted to reserve roster | | | Before |
| 5/26/2021 | PEA | Fuentes | Activated from Injured List | | | Before |
| 5/26/2021 | PEA | Pujols | Demoted to reserve roster | | | Before |
| 5/26/2021 | PEA | Springer | Activated from Injured List | | | Before |
| 5/26/2021 | TOR | Gonzalez,V | Demoted to reserve roster | | | Before |
| 5/26/2021 | TOR | Suarez,J | Promoted to active roster | | | Before |
| 5/28/2021 | DRB | Alberto | Traded away | TOR | | After |
| 5/28/2021 | DRB | Braun | Acquired via trade | NDF | | After |
| 5/28/2021 | DRB | Cano | Acquired via trade | TOR | | After |
| 5/28/2021 | DRB | Delmonico | Traded away | TOR | | After |
| 5/28/2021 | DRB | King,M | Traded away | TOR | | After |
| 5/28/2021 | DRB | LeMahieu | Acquired via trade | TOR | | After |
| 5/28/2021 | DRB | McBroom | Acquired via trade | TOR | | After |
| 5/28/2021 | DRB | Riley | Traded away | TOR | | After |
| 5/28/2021 | DRB | Sanchez,G | Traded away | TOR | | After |
| 5/28/2021 | DRB | Shaw,B | Traded away | NDF | | After |
| 5/28/2021 | DRB | Suzuki | Acquired via trade | NDF | | After |
| 5/28/2021 | DRB | Taylor,M | Traded away | NDF | | After |
| 5/28/2021 | DRB | Winker | Traded away | TOR | | After |
| 5/28/2021 | NDF | Braun | Traded away | DRB | | After |
| 5/28/2021 | NDF | Greiner | Acquired via trade | TOR | | After |
| 5/28/2021 | NDF | Shaw,B | Acquired via trade | DRB | | After |
| 5/28/2021 | NDF | Suzuki | Traded away | DRB | | After |
| 5/28/2021 | NDF | Taylor,M | Acquired via trade | DRB | | After |
| 5/28/2021 | TOR | Alberto | Acquired via trade | DRB | | After |
| 5/28/2021 | TOR | Cano | Traded away | DRB | | After |
| 5/28/2021 | TOR | Delmonico | Acquired via trade | DRB | | After |
| 5/28/2021 | TOR | Greiner | Traded away | NDF | | After |
| 5/28/2021 | TOR | King,M | Acquired via trade | DRB | | After |
| 5/28/2021 | TOR | LeMahieu | Traded away | DRB | | After |
| 5/28/2021 | TOR | McBroom | Traded away | DRB | | After |
| 5/28/2021 | TOR | Riley | Acquired via trade | DRB | | After |
| 5/28/2021 | TOR | Sanchez,G | Acquired via trade | DRB | | After |
| 5/28/2021 | TOR | Winker | Acquired via trade | DRB | | After |
| 5/29/2021 | DRB | Carrasco | Promoted to active roster | | | Before |
| 5/29/2021 | DRB | Hendriks | Demoted to reserve roster | | | Before |
| 5/29/2021 | DRB | Roe | Promoted to active roster | | | Before |
| 5/29/2021 | DRB | Stripling | Demoted to reserve roster | | | Before |
| 5/29/2021 | NHP | Musgrove | Activated from Injured List | | | Before |
| 5/29/2021 | NHP | Paddack | Demoted to reserve roster | | | Before |
| 5/29/2021 | TOR | Gonzalez,V | Promoted to active roster | | | Before |
| 5/29/2021 | TOR | Higashioka | Promoted to active roster | | | Before |
| 5/29/2021 | TOR | Kelly,C | Demoted to reserve roster | | | Before |
| 5/29/2021 | TOR | King,M | Promoted to active roster | | | Before |
| 5/29/2021 | TOR | Martinez,C | Demoted to reserve roster | | | Before |
| 5/29/2021 | TOR | Paredes,I | Promoted to active roster | | | Before |
| 5/29/2021 | TOR | Sanchez,G | Demoted to reserve roster | | | Before |
| 5/29/2021 | TOR | Sanchez,G | Promoted to active roster | | | Before |
| 5/29/2021 | TOR | Sherriff | Demoted to reserve roster | | | Before |
| 5/29/2021 | TOR | Suarez,J | Demoted to reserve roster | | | Before |
| 5/29/2021 | TOR | Tropeano | Promoted to active roster | | | Before |
| 6/1/2021 | DRB | Gonzalez,E | Demoted to reserve roster | | | Before |
| 6/1/2021 | DRB | Hechavarria | Demoted to reserve roster | | | Before |
| 6/1/2021 | DRB | Hendriks | Promoted to active roster | | | Before |
| 6/1/2021 | DRB | Roe | Demoted to reserve roster | | | Before |
| 6/1/2021 | TOR | Alberto | Activated from Injured List | | | Before |
| 6/1/2021 | TOR | Haggerty | Demoted to reserve roster | | | Before |
| 6/1/2021 | TOR | Higashioka | Demoted to reserve roster | | | Before |
| 6/1/2021 | TOR | Kelly,C | Promoted to active roster | | | Before |
| 6/1/2021 | TOR | Martinez,C | Promoted to active roster | | | Before |
| 6/1/2021 | TOR | Merryweather | Demoted to reserve roster | | | Before |
| 6/4/2021 | CED | Barria | Promoted to active roster | | | Before |
| 6/4/2021 | CED | Brault | Placed on Injured List | | 6/4/2021 | Before |
| 6/4/2021 | CED | Brosseau | Demoted to reserve roster | | | Before |
| 6/4/2021 | CED | Bubic | Promoted to active roster | | | Before |
| 6/4/2021 | CED | Castillo,D | Demoted to reserve roster | | | Before |
| 6/4/2021 | CED | Evans,P | Promoted to active roster | | | Before |
| 6/4/2021 | CED | Herget | Promoted to active roster | | | Before |
| 6/4/2021 | CED | Peterson,J | Demoted to reserve roster | | | Before |
| 6/7/2021 | DRB | Gonzalez,E | Promoted to active roster | | | Before |
| 6/7/2021 | DRB | Hechavarria | Promoted to active roster | | | Before |
| 6/7/2021 | DRB | Iglesias,J | Placed on Injured List | | 6/7/2021 | Before |
| 6/7/2021 | DRB | McBroom | Demoted to reserve roster | | | Before |
| 6/7/2021 | NHP | Gardner | Placed on Injured List | | 6/5/2021 | Before |
| 6/7/2021 | NHP | Locastro | Promoted to active roster | | | Before |
| 6/7/2021 | TOR | Gonzalez,V | Demoted to reserve roster | | | Before |
| 6/7/2021 | TOR | Keller,M | Demoted to reserve roster | | | Before |
| 6/7/2021 | TOR | Merryweather | Promoted to active roster | | | Before |
| 6/7/2021 | TOR | Strasburg | Promoted to active roster | | | Before |
| 6/7/2021 | TOR | Suarez,J | Promoted to active roster | | | Before |
| 6/7/2021 | TOR | Tropeano | Demoted to reserve roster | | | Before |
| 6/10/2021 | CED | Gallagher | Activated from Injured List | | | Before |
| 6/10/2021 | CED | Hedges | Demoted to reserve roster | | | Before |
| 6/10/2021 | DRB | Anderson,I | Demoted to reserve roster | | | Before |
| 6/10/2021 | DRB | Avila | Promoted to active roster | | | Before |
| 6/10/2021 | DRB | Castro,S | Demoted to reserve roster | | | Before |
| 6/10/2021 | DRB | Hendriks | Demoted to reserve roster | | | Before |
| 6/10/2021 | DRB | Heredia | Promoted to active roster | | | Before |
| 6/10/2021 | DRB | Marisnick | Demoted to reserve roster | | | Before |
| 6/10/2021 | DRB | Peacock | Promoted to active roster | | | Before |
| 6/10/2021 | DRB | Roe | Promoted to active roster | | | Before |
| 6/10/2021 | DRB | Stripling | Promoted to active roster | | | Before |
| 6/10/2021 | DRB | Tellez | Demoted to reserve roster | | | Before |
| 6/16/2021 | TOR | Cabrera,G | Placed on Injured List | | 6/15/2021 | Before |
| 6/16/2021 | TOR | Haggerty | Promoted to active roster | | | Before |
| 6/16/2021 | TOR | Keller,M | Promoted to active roster | | | Before |
| 6/16/2021 | TOR | Merryweather | Demoted to reserve roster | | | Before |
| 6/16/2021 | TOR | Sherriff | Promoted to active roster | | | Before |
| 6/16/2021 | TOR | Suarez,J | Demoted to reserve roster | | | Before |
| 6/19/2021 | CED | Brosseau | Promoted to active roster | | | Before |
| 6/19/2021 | CED | Castillo,D | Promoted to active roster | | | Before |
| 6/19/2021 | CED | Evans,P | Placed on Injured List | | 6/19/2021 | Before |
| 6/19/2021 | CED | Fulmer,C | Promoted to active roster | | | Before |
| 6/19/2021 | CED | Hill,C | Demoted to reserve roster | | | Before |
| 6/19/2021 | CED | May,T | Demoted to reserve roster | | | Before |
| 6/19/2021 | DRB | Anderson,I | Promoted to active roster | | | Before |
| 6/19/2021 | DRB | Bailey,H | Promoted to active roster | | | Before |
| 6/19/2021 | DRB | Gonzalez,E | Demoted to reserve roster | | | Before |
| 6/19/2021 | DRB | Hendriks | Promoted to active roster | | | Before |
| 6/19/2021 | DRB | Heredia | Demoted to reserve roster | | | Before |
| 6/19/2021 | DRB | Marisnick | Promoted to active roster | | | Before |
| 6/19/2021 | DRB | Maybin | Demoted to reserve roster | | | Before |
| 6/19/2021 | DRB | McBroom | Promoted to active roster | | | Before |
| 6/19/2021 | DRB | Peacock | Demoted to reserve roster | | | Before |
| 6/19/2021 | DRB | Roe | Demoted to reserve roster | | | Before |
| 6/19/2021 | DRB | Stripling | Demoted to reserve roster | | | Before |
| 6/19/2021 | DRB | Tellez | Promoted to active roster | | | Before |
| 6/22/2021 | DRB | Hechavarria | Demoted to reserve roster | | | Before |
| 6/22/2021 | DRB | Iglesias,J | Activated from Injured List | | | Before |
| 6/25/2021 | DRB | Anderson,I | Demoted to reserve roster | | | Before |
| 6/25/2021 | DRB | Britton | Demoted to reserve roster | | | Before |
| 6/25/2021 | DRB | Gonzalez,E | Promoted to active roster | | | Before |
| 6/25/2021 | DRB | Stripling | Promoted to active roster | | | Before |
| 6/25/2021 | NHP | Gardner | Activated from Injured List | | | Before |
| 6/25/2021 | NHP | Locastro | Demoted to reserve roster | | | Before |
| 6/25/2021 | PEA | Arauz | Demoted to reserve roster | | | Before |
| 6/25/2021 | PEA | Odor | Activated from Injured List | | | Before |
| 6/28/2021 | CED | Brault | Activated from Injured List | | | Before |
| 6/28/2021 | CED | Buehler | Demoted to reserve roster | | | Before |
| 6/28/2021 | CED | Eflin | Placed on Injured List | | 6/28/2021 | Before |
| 6/28/2021 | CED | May,T | Promoted to active roster | | | Before |
| 6/28/2021 | CED | Ramirez,E | Promoted to active roster | | | Before |
| 6/28/2021 | CED | Valdez,C | Demoted to reserve roster | | | Before |
| 6/28/2021 | TOR | Gonzalez,V | Promoted to active roster | | | Before |
| 6/28/2021 | TOR | Higashioka | Promoted to active roster | | | Before |
| 6/28/2021 | TOR | Kelly,C | Demoted to reserve roster | | | Before |
| 6/28/2021 | TOR | Merryweather | Promoted to active roster | | | Before |
| 6/28/2021 | TOR | Paredes,I | Demoted to reserve roster | | | Before |
| 6/28/2021 | TOR | Sherriff | Demoted to reserve roster | | | Before |
| 6/28/2021 | TOR | Strasburg | Demoted to reserve roster | | | Before |
| 6/28/2021 | TOR | Tropeano | Promoted to active roster | | | Before |
| 7/1/2021 | DRB | Hicks | Placed on Injured List | | 7/1/2021 | Before |
| 7/1/2021 | DRB | Maybin | Promoted to active roster | | | Before |
| 7/4/2021 | DRB | Britton | Promoted to active roster | | | Before |
| 7/4/2021 | DRB | Hendriks | Demoted to reserve roster | | | Before |
| 7/4/2021 | DRB | Miller,A | Demoted to reserve roster | | | Before |
| 7/4/2021 | DRB | Peacock | Promoted to active roster | | | Before |
| 7/4/2021 | DRB | Roe | Demoted to reserve roster | | | Before |
| 7/4/2021 | DRB | Roe | Promoted to active roster | | | Before |
| 7/4/2021 | DRB | Roe | Promoted to active roster | | | Before |
| 7/4/2021 | TOR | Cabrera,G | Activated from Injured List | | | Before |
| 7/4/2021 | TOR | Martinez,C | Demoted to reserve roster | | | Before |
| 7/7/2021 | CED | Albies | Placed on Injured List | | 7/7/2021 | Before |
| 7/7/2021 | CED | Owings | Promoted to active roster | | | Before |
| 7/10/2021 | CED | Brosseau | Demoted to reserve roster | | | Before |
| 7/10/2021 | CED | Eflin | Activated from Injured List | | | Before |
| 7/10/2021 | CED | Evans,P | Activated from Injured List | | | Before |
| 7/10/2021 | CED | May,T | Demoted to reserve roster | | | Before |
| 7/12/2021 | NHP | Sanchez,J | Traded away | OLL | | After |
| 7/12/2021 | NHP | Smith,Do | Acquired via trade | OLL | | After |
| 7/13/2021 | DRB | Avila | Demoted to reserve roster | | | Before |
| 7/13/2021 | DRB | Avila | Promoted to active roster | | | Before |
| 7/13/2021 | DRB | Avila | Demoted to reserve roster | | | Before |
| 7/13/2021 | DRB | Hechavarria | Promoted to active roster | | | Before |
| 7/13/2021 | DRB | Hicks | Activated from Injured List | | | Before |
| 7/13/2021 | DRB | Marisnick | Demoted to reserve roster | | | Before |
| 7/13/2021 | NHP | Urias,L | Demoted to reserve roster | | | Before |
| 7/13/2021 | TOR | Gonzalez,V | Demoted to reserve roster | | | Before |
| 7/13/2021 | TOR | Haggerty | Demoted to reserve roster | | | Before |
| 7/13/2021 | TOR | Higashioka | Demoted to reserve roster | | | Before |
| 7/13/2021 | TOR | Kelly,C | Promoted to active roster | | | Before |
| 7/13/2021 | TOR | Luplow | Promoted to active roster | | | Before |
| 7/13/2021 | TOR | Martinez,C | Promoted to active roster | | | Before |
| 7/13/2021 | TOR | Merryweather | Demoted to reserve roster | | | Before |
| 7/13/2021 | TOR | Strasburg | Promoted to active roster | | | Before |
| 7/13/2021 | TOR | Suarez,J | Promoted to active roster | | | Before |
| 7/13/2021 | TOR | Tropeano | Demoted to reserve roster | | | Before |
| 7/15/2021 | LKE | Hand | Traded away | CAL | | After |
| 7/15/2021 | LKE | Pederson | Acquired via trade | CAL | | After |
| 7/15/2021 | TOR | Barnes,M | Acquired via trade | CAL | | After |
| 7/15/2021 | TOR | Gonzalez,V | Traded away | CAL | | After |
| 7/15/2021 | TOR | Jansen,K | Acquired via trade | CAL | | After |
| 7/15/2021 | TOR | Kratz | Acquired via trade | CAL | | After |
| 7/15/2021 | TOR | Mills | Acquired via trade | CAL | | After |
| 7/15/2021 | TOR | Porcello | Traded away | CAL | | After |
| 7/15/2021 | TOR | Staumont | Traded away | CAL | | After |
| 7/16/2021 | DRB | Avila | Promoted to active roster | | | Before |
| 7/16/2021 | DRB | Gant | Demoted to reserve roster | | | Before |
| 7/16/2021 | NHP | Alzolay | Demoted to reserve roster | | | Before |
| 7/16/2021 | NHP | Locastro | Promoted to active roster | | | Before |
| 7/16/2021 | NHP | Madrigal | Placed on Injured List | | 7/14/2021 | Before |
| 7/16/2021 | NHP | Paddack | Promoted to active roster | | | Before |
| 7/16/2021 | TOR | Suarez,J | Demoted to reserve roster | | | Before |
| 7/16/2021 | WTB | Adell | Promoted to active roster | | | Before |
| 7/16/2021 | WTB | Burrows | Promoted to active roster | | | Before |
| 7/16/2021 | WTB | Hayes | Demoted to reserve roster | | | Before |
| 7/16/2021 | WTB | Santana,Do | Demoted to reserve roster | | | Before |
| 7/18/2021 | HAV | Farmer,K | Acquired via trade | HOL | | After |
| 7/18/2021 | HAV | Hale | Traded away | HOL | | After |
| 7/18/2021 | LKE | Alonso | Acquired via trade | CLE | | After |
| 7/18/2021 | LKE | Beaty | Acquired via trade | CLE | | After |
| 7/18/2021 | LKE | Castillo,L | Acquired via trade | CLE | | After |
| 7/18/2021 | LKE | Davies | Traded away | CLE | | After |
| 7/18/2021 | LKE | Fleming | Acquired via trade | CLE | | After |
| 7/18/2021 | LKE | Jeffress | Traded away | CLE | | After |
| 7/18/2021 | LKE | Keuchel | Traded away | CLE | | After |
| 7/18/2021 | LKE | Lorenzen | Acquired via trade | CLE | | After |
| 7/18/2021 | LKE | McKinney | Acquired via trade | CLE | | After |
| 7/18/2021 | LKE | Ryan | Acquired via trade | CLE | | After |
| 7/18/2021 | LKE | Sanchez,Y | Acquired via trade | CLE | | After |
| 7/18/2021 | NHP | Jefferies | Traded away | OLL | | After |
| 7/18/2021 | NHP | Santander | Acquired via trade | OLL | | After |
| 7/19/2021 | DRB | Anderson,I | Promoted to active roster | | | Before |
| 7/19/2021 | DRB | Bailey,H | Demoted to reserve roster | | | Before |
| 7/19/2021 | DRB | Castro,S | Promoted to active roster | | | Before |
| 7/19/2021 | DRB | Gant | Promoted to active roster | | | Before |
| 7/19/2021 | DRB | Gonzalez,E | Demoted to reserve roster | | | Before |
| 7/19/2021 | DRB | Hechavarria | Demoted to reserve roster | | | Before |
| 7/19/2021 | DRB | Hendriks | Promoted to active roster | | | Before |
| 7/19/2021 | DRB | Marisnick | Promoted to active roster | | | Before |
| 7/19/2021 | DRB | Maybin | Demoted to reserve roster | | | Before |
| 7/19/2021 | DRB | Miller,A | Promoted to active roster | | | Before |
| 7/19/2021 | DRB | Peacock | Demoted to reserve roster | | | Before |
| 7/19/2021 | DRB | Roe | Demoted to reserve roster | | | Before |
| 7/19/2021 | DRB | Stripling | Demoted to reserve roster | | | Before |
| 7/19/2021 | HAV | Hiura | Demoted to reserve roster | | | Before |
| 7/19/2021 | NHP | Gardner | Demoted to reserve roster | | | Before |
| 7/19/2021 | SPR | Milone | Promoted to active roster | | | Before |
| 7/19/2021 | SPR | Pineda | Demoted to reserve roster | | | Before |
| 7/22/2021 | DRB | Anderson,I | Demoted to reserve roster | | | Before |
| 7/22/2021 | DRB | Gonzalez,E | Promoted to active roster | | | Before |
| 7/22/2021 | DRB | Stripling | Promoted to active roster | | | Before |
| 7/22/2021 | DRB | Tellez | Placed on Injured List | | 7/20/2021 | Before |
| 7/22/2021 | NHP | Locastro | Demoted to reserve roster | | | Before |
| 7/22/2021 | NHP | Montas | Promoted to active roster | | | Before |
| 7/25/2021 | CED | Buehler | Promoted to active roster | | | Before |
| 7/25/2021 | CED | Eflin | Demoted to reserve roster | | | Before |
| 7/28/2021 | CED | Albies | Activated from Injured List | | | Before |
| 7/28/2021 | CED | Owings | Demoted to reserve roster | | | Before |
| 7/28/2021 | DRB | Hechavarria | Promoted to active roster | | | Before |
| 7/28/2021 | DRB | Iglesias,J | Placed on Injured List | | 7/26/2021 | Before |
| 7/31/2021 | DRB | Anderson,I | Promoted to active roster | | | Before |
| 7/31/2021 | DRB | Stripling | Demoted to reserve roster | | | Before |
| 7/31/2021 | TOR | Strasburg | Demoted to reserve roster | | | Before |
| 7/31/2021 | TOR | Tropeano | Promoted to active roster | | | Before |
| 8/3/2021 | TOR | Martinez,C | Placed on Injured List | | 8/3/2021 | Before |
| 8/3/2021 | TOR | Merryweather | Promoted to active roster | | | Before |
| 8/6/2021 | DRB | Castro,S | Demoted to reserve roster | | | Before |
| 8/6/2021 | DRB | Maybin | Promoted to active roster | | | Before |
| 8/6/2021 | NHP | Castro,J | Demoted to reserve roster | | | Before |
| 8/6/2021 | NHP | Garcia,LV | Demoted to reserve roster | | | Before |
| 8/6/2021 | NHP | Kirk | Promoted to active roster | | | Before |
| 8/6/2021 | NHP | Madrigal | Activated from Injured List | | | Before |
| 8/6/2021 | NHP | Peralta,F | Demoted to reserve roster | | | Before |
| 8/6/2021 | NHP | Ray | Promoted to active roster | | | Before |
| 8/6/2021 | TOR | Higashioka | Promoted to active roster | | | Before |
| 8/6/2021 | TOR | Kelly,C | Demoted to reserve roster | | | Before |
| 8/9/2021 | CED | Brosseau | Promoted to active roster | | | Before |
| 8/9/2021 | CED | Evans,P | Demoted to reserve roster | | | Before |
| 8/9/2021 | DRB | Anderson,I | Demoted to reserve roster | | | Before |
| 8/9/2021 | DRB | Stripling | Promoted to active roster | | | Before |
| 8/9/2021 | SPR | Kim | Demoted to reserve roster | | | Before |
| 8/9/2021 | SPR | Robles,H | Promoted to active roster | | | Before |
| 8/9/2021 | WTB | Bichette | Demoted to reserve roster | | | Before |
| 8/9/2021 | WTB | Rodgers | Promoted to active roster | | | Before |
| 8/12/2021 | LKE | Allard | Promoted to active roster | | | Before |
| 8/12/2021 | LKE | Fleming | Promoted to active roster | | | Before |
| 8/12/2021 | LKE | Kimbrel | Promoted to active roster | | | Before |
| 8/12/2021 | LKE | Lorenzen | Promoted to active roster | | | Before |
| 8/12/2021 | LKE | McKenzie | Demoted to reserve roster | | | Before |
| 8/15/2021 | TOR | Haggerty | Promoted to active roster | | | Before |
| 8/15/2021 | TOR | Haseley | Demoted to reserve roster | | | Before |
| 8/15/2021 | TOR | Kelly,C | Promoted to active roster | | | Before |
| 8/15/2021 | TOR | Merryweather | Demoted to reserve roster | | | Before |
| 8/18/2021 | DRB | Anderson,I | Promoted to active roster | | | Before |
| 8/18/2021 | DRB | Stripling | Demoted to reserve roster | | | Before |
| 8/18/2021 | HAV | Cobb | Placed on Injured List | | 8/18/2021 | Before |
| 8/18/2021 | HAV | Strahm | Promoted to active roster | | | Before |
| 8/18/2021 | NHP | Locastro | Promoted to active roster | | | Before |
| 8/18/2021 | NHP | Montero | Demoted to reserve roster | | | Before |
| 8/21/2021 | CED | Fulmer,C | Demoted to reserve roster | | | Before |
| 8/21/2021 | CED | May,T | Promoted to active roster | | | Before |
| 8/21/2021 | CED | Ramirez,E | Demoted to reserve roster | | | Before |
| 8/21/2021 | CED | Valdez,C | Promoted to active roster | | | Before |
| 8/21/2021 | DRB | Marisnick | Demoted to reserve roster | | | Before |
| 8/21/2021 | DRB | Tellez | Activated from Injured List | | | Before |
| 8/24/2021 | DRB | Marisnick | Promoted to active roster | | | Before |
| 8/24/2021 | DRB | McBroom | Demoted to reserve roster | | | Before |
| 8/24/2021 | TOR | Keller,M | Demoted to reserve roster | | | Before |
| 8/24/2021 | TOR | Martinez,C | Activated from Injured List | | | Before |
| 8/24/2021 | TOR | Riley | Placed on Injured List | | 8/19/2021 | Before |
| 8/24/2021 | TOR | Toro | Promoted to active roster | | | Before |
| 8/24/2021 | WTB | Baez,P | Demoted to reserve roster | | | Before |
| 8/24/2021 | WTB | Bickford | Promoted to active roster | | | Before |
| 8/24/2021 | WTB | Ervin | Promoted to active roster | | | Before |
| 8/24/2021 | WTB | Garcia,Y | Demoted to reserve roster | | | Before |
| 8/24/2021 | WTB | Jackson,A | Promoted to active roster | | | Before |
| 8/24/2021 | WTB | Knapp | Demoted to reserve roster | | | Before |
| 8/24/2021 | WTB | Medina | Promoted to active roster | | | Before |
| 8/24/2021 | WTB | Soroka | Demoted to reserve roster | | | Before |
| 8/27/2021 | CED | Bubic | Demoted to reserve roster | | | Before |
| 8/27/2021 | CED | Buehler | Demoted to reserve roster | | | Before |
| 8/27/2021 | CED | Eflin | Promoted to active roster | | | Before |
| 8/27/2021 | CED | Hill,C | Promoted to active roster | | | Before |
| 8/27/2021 | CED | Owings | Promoted to active roster | | | Before |
| 8/27/2021 | CED | Valdez,C | Demoted to reserve roster | | | Before |
| 8/27/2021 | NHP | Castro,J | Promoted to active roster | | | Before |
| 8/27/2021 | NHP | Kirk | Placed on Injured List | | 8/25/2021 | Before |
| 8/30/2021 | CED | Bubic | Promoted to active roster | | | Before |
| 8/30/2021 | CED | Owings | Demoted to reserve roster | | | Before |
| 9/2/2021 | NHP | Gardner | Promoted to active roster | | | Before |
| 9/2/2021 | NHP | Locastro | Demoted to reserve roster | | | Before |
| 9/2/2021 | NHP | Smith,WM | Demoted to reserve roster | | | Before |
| 9/2/2021 | NHP | Urias,L | Promoted to active roster | | | Before |
| 9/5/2021 | DRB | Anderson,C | Promoted to active roster | | | Before |
| 9/5/2021 | DRB | Anderson,I | Demoted to reserve roster | | | Before |
| 9/5/2021 | DRB | Avila | Demoted to reserve roster | | | Before |
| 9/5/2021 | DRB | Bailey,H | Promoted to active roster | | | Before |
| 9/5/2021 | DRB | Braun | Demoted to reserve roster | | | Before |
| 9/5/2021 | DRB | Braun | Promoted to active roster | | | Before |
| 9/5/2021 | DRB | Britton | Demoted to reserve roster | | | Before |
| 9/5/2021 | DRB | Cano | Demoted to reserve roster | | | Before |
| 9/5/2021 | DRB | Gant | Demoted to reserve roster | | | Before |
| 9/5/2021 | DRB | Hendriks | Demoted to reserve roster | | | Before |
| 9/5/2021 | DRB | Heredia | Promoted to active roster | | | Before |
| 9/5/2021 | DRB | LeMahieu | Demoted to reserve roster | | | Before |
| 9/5/2021 | DRB | Marisnick | Demoted to reserve roster | | | Before |
| 9/5/2021 | DRB | May,D | Demoted to reserve roster | | | Before |
| 9/5/2021 | DRB | McBroom | Promoted to active roster | | | Before |
| 9/5/2021 | DRB | Miller,A | Demoted to reserve roster | | | Before |
| 9/5/2021 | DRB | Peacock | Promoted to active roster | | | Before |
| 9/5/2021 | DRB | Roe | Promoted to active roster | | | Before |
| 9/5/2021 | DRB | Romano,S | Promoted to active roster | | | Before |
| 9/5/2021 | DRB | Stripling | Promoted to active roster | | | Before |
| 9/5/2021 | DRB | Tellez | Demoted to reserve roster | | | Before |
| 9/5/2021 | DRB | Tellez | Promoted to active roster | | | Before |
| 9/5/2021 | NHP | Belt | Demoted to reserve roster | | | Before |
| 9/5/2021 | NHP | Garcia,LV | Promoted to active roster | | | Before |
| 9/5/2021 | NHP | Kirk | Activated from Injured List | | | Before |
| 9/5/2021 | NHP | Madrigal | Demoted to reserve roster | | | Before |
| 9/5/2021 | NHP | Musgrove | Demoted to reserve roster | | | Before |
| 9/5/2021 | NHP | Santander | Demoted to reserve roster | | | Before |
| 9/5/2021 | NHP | Smith,P | Promoted to active roster | | | Before |
| 9/5/2021 | NHP | Smith,WD | Demoted to reserve roster | | | Before |
| 9/5/2021 | NHP | Thornton | Promoted to active roster | | | Before |
| 9/5/2021 | NHP | Urshela | Demoted to reserve roster | | | Before |
| 9/5/2021 | NHP | Wendelken | Demoted to reserve roster | | | Before |
| 9/5/2021 | NHP | White,Ev | Promoted to active roster | | | Before |
| 9/11/2021 | CED | Albies | Demoted to reserve roster | | | Before |
| 9/11/2021 | CED | Barria | Demoted to reserve roster | | | Before |
| 9/11/2021 | CED | Choo | Demoted to reserve roster | | | Before |
| 9/11/2021 | CED | Evans,D | Promoted to active roster | | | Before |
| 9/11/2021 | CED | Fisher | Promoted to active roster | | | Before |
| 9/11/2021 | CED | Garcia,Jo | Promoted to active roster | | | Before |
| 9/11/2021 | CED | Hays | Demoted to reserve roster | | | Before |
| 9/11/2021 | CED | Hedges | Promoted to active roster | | | Before |
| 9/11/2021 | CED | Owings | Promoted to active roster | | | Before |
| 9/11/2021 | CED | Pagan | Demoted to reserve roster | | | Before |
| 9/11/2021 | CED | Perez,S | Demoted to reserve roster | | | Before |
| 9/11/2021 | CED | Voth | Promoted to active roster | | | Before |